NK – Human Natural Killer Cells

Supplier: LONZA PHARMA - BIOSCIENCE CA

2W-502
CA10065-204EA 2097.45 CAD
CA10065-204
NK – Human Natural Killer Cells
Cells

Natural Killer (NK) cells are lymphocytes of the immune system that are critical in host defense and immune regulation as part of both the innate and adaptive immune response.


  • HIV-1, hepatitis B and hepatitis C are not detected for all donors and/or cell lots


They are of particular interest to immunotherapy researchers as they hold the promise to specifically target and destroy cancer cells and tumors while leaving healthy cells intact. Cells You Can Count on to Perform Natural Killer cells are traditionally characterized by the presence of the CD56 cell surface marker and absence of CD3. In addition, CD16 is important for NK cell function because CD16 induces cytokine expression and cytotoxic effector activity. Lonza NK cells are isolated using positive (2W-502) or negative (2W-501) immunomagnetic selection for the CD56 marker. Purity is ≥90% based on the presence of CD56+ cells. Both positively and negatively selected NK cells are guaranteed to express CD56 and CD16. However, negative immunomagnetic separation of NK cells results in significantly greater enrichment of CD16+ cells (typically > 80% of total cells), whereas expression of CD16 is variable with the positively selected NK cells. Lonza NK cells are guaranteed to express CD56 and CD16, and contain ≥5 million viable cells per vial.


Supported by Lonza Medium LGM-3® Lymphocyte Growth Medium is recommended for optimal performance of NK cells. Additional cytokines may be necessary depending on application.


Lonza guarantees the performance of Clonetics®/Poietics® cells only if appropriate Clonetics®/Poietics® media and reagents are used exclusively and the recommended storage and use protocols are followed.


Delivery information: Content: 5 million cells/vial. A Certificate of Analysis is provided for each cell lot purchased.

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